申纪饶,武小虎,张惠婷,李新圃,丁学智,严作廷,李宏胜

• 1:中国农业科学院兰州畜牧与兽药研究所/农业部兽用药物创制重点实验室/甘肃省新兽药工程重点实验室

摘要(Abstract)：

奶牛乳腺炎是奶牛最常见的疾病之一,可造成奶产量和质量下降,给奶牛养殖业造成巨大的经济损失。目前,对奶牛乳腺炎的治疗以抗生素为主,但由于抗生素的滥用,造成病原菌耐药及药物残留,给奶牛乳腺炎防控及公共卫生安全造成威胁。由于中药具有低毒、低残留、细菌不易产生耐药性及治疗效果明确等特点,近年来成为众多国内外学者研究的方向,尤其是以牛乳腺上皮细胞(bMEC)为模型开展的中药作用机制及作用靶点的研究已成为热点。文章对牛乳腺上皮细胞培养特性、乳腺炎炎症模型的建立、中药在干预细胞模型及作用靶点方面的最新进展、未来研究前景等方面进行了综述,以期为进一步深入研究中药治疗奶牛乳腺炎作用机制及筛选优良的中药方剂提供参考。

关键词(KeyWords)： 奶牛乳腺炎;细胞模型;中药;作用机制;干预

Abstract:

Keywords:

基金项目(Foundation): 甘肃省重点研发-国际科技合作项目(21YF5WA144);; 畜禽主要疾病绿色高效防治技术研究与应用项目(CAAS-LMY-02);; 中国农业科学院奶牛疾病研究创新工程项目(CAAS-ASTIP-2014-LIHPS-03)

作者(Author): 申纪饶,武小虎,张惠婷,李新圃,丁学智,严作廷,李宏胜

DOI: 10.19848/j.cnki.ISSN1005-2739.2021.10.0002

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